GPC Journal Club

Generalist-Primary Care Journal Club

The GPC Journal Club is led by GPC residents and faculty and fellows from the Division of General Medicine on a monthly or bi-monthly basis to discuss current literature applicable to the practice of general medicine. Below is a list of the articles discussed. 


7/18 Evaluation of the Pooled Cohort Risk Equations for Cardiovascular Risk Prediction in a Multiethnic Cohort From the Women’s Health Initiative. JAMA 2018

8/18 Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes. JAMA 2018

8/18 Clinicians' Perspectives on Providing Emergency-Only Hemodialysis to Undocumented Immigrants. Ann Intern Med. 2018

8/18 Assessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit. A Multicenter Population-Based Cohort Study. JAMA 2018

9/18 Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet 2015

10/18 Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes. NEJM 2017

10/18 Effect of Aspirin on Disability-free Survival in the Healthy Elderly. NEJM 2018

Effect of Aspirin on All-Cause Mortality  in the Healthy Elderly. NEJM 2018

11/18 Effect of a Remotely Delivered Tailored Multicomponent Approach to Enhance Medication Taking for Patients With Hyperlipidemia, Hypertension, and Diabetes. JAMA 2018

12/18 Gait Speed and Survival in Older Adults. JAMA 2011

1/19 A Cluster-Randomized Trial of BloodPressure Reduction in Black Barbershops. NEJM 2018


7/17 Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 2 Diabetes. The SWITCH 2 Randomized Clinical Trial. JAMA 2016

8/17 Structural racism and health inequities in the USA: evidence and interventions. Lancet 2017

8/17 Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review. Lancet 2017

9/17 Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of Sepsis

10/17 Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial

11/17 Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults JAMA 2017

12/17 Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of SepsisA Randomized Clinical Trial. JAMA 2016

2/18 Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists. JAMA 2017

4/18 Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations. NEJM March 8, 2018

4/18 Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain The SPACE Randomized Clinical Trial. JAMA 2018

5/18 Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality. NEJM April 19, 2018


9/2016 Association of Proton Pump Inhibitors With Risk of DementiaA Pharmacoepidemiological Claims Data Analysis JAMA 2016

7/2016 United States Health Care Reform Progress to Date and Next Steps by Barack Obama, JD NEJM

9/16 A Randomized Trial of Intensive versus Standard Blood-Pressure Control NEJM 11/15

1/17: "Appointment Availability after Increases in Medicaid Payments for Primary Care" NEJM 2016

2/17 N Engl J Med. 2016 Oct 27;375(17):1617-1627.

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.

Thorax. 2015 May;70(5):492-4. doi: 10.1136/thoraxjnl-2014-205720. Epub 2014 Dec 3.

Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.

3/17: Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma

Shawn D. Aaron, MD1; Katherine L. Vandemheen, MScN1; J. Mark FitzGerald, MD2; et al JAMA 2016

4/17 Early Performance of Accountable Care Organizations in Medicare NEJM 2016

6/17 The Oregon Experiment — Effects of Medicaid on Clinical Outcomes Katherine Baicker, Ph.D., Sarah L. Taubman, Sc.D., Heidi L. Allen, Ph.D., NEJM 201



7/25/14 Medicine and the Epidemic of Incarceration in the United States, NEJM, 2011

Release from Prison — A High Risk of Death for Former Inmates, NEJM, 2007

8/21/14 Housing as Healthcare, Public Roles of Physicians

9/5/14 Transforming Primary Care: From Past Practice To The Practice Of The Future. Health Affairs, 2010

10/31/14 Health diplomacy: a new approach to the Muslim world? Globalization and Health, 2014

11/14/14 From personal survival to public health: community leadership by men who have sex with men in the response to HIV. Lancet, 2012

12/17/14 Blocker Use and Clinical Outcomes in Stable Outpatients With and Without Coronary Artery Disease JAMA, 2010

1/21/15 Dying with Dignity in the Intensive Care Unit, NEJM, 2014

The world’s major religions’ points of view on end-of-life decisions in the intensive care unit. Intensive Care Medicine, 2007

2/20/15 Neighborhood Socioeconomic Disadvantage and 30-Day Rehospitalization, Annals, 2014

3/17/15 Finding the Right Words at the Right Time — High-Value Advance Care Planning, NEJM

Change in End-of-Life Care for Medicare Beneficiaries Site of Death, Place of Care, and Health Care Transitions in 2000, 2005, and 2009. JAMA 2013

4/20/15 ‘‘Oops! I forgot HIV’’: Resident physician self-audits and universal HIV screening” Journal of Infection and Public Health, 2015

9/6/13 The Oregon Experiment - Effects of Medicaid Expansion on Clinical Outcomes. NEJM, May 2013

12/12/13 Crossing Boundaries- Violation or Obligation? JAMA, Sept 2013

2/25/14 Joint National Commission HTN Guidelines and Commentary

3/8/2014 Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ, 2014

3/18/2014 Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline. Annals, 2014

7/20/12 High-Value, Cost-Conscious Health Care: Concepts for Clinicians to Evaluate the Benefits, Harms, and Costs of Medical Interventions , Annals

Appropriate Use of Screening and Diagnostic Tests to Foster High-Value, Cost-Conscious Care

8/17/12 Spencer et al. Effectiveness of a Community Health Worker Intervention Among African American and Latino Adults with Type 2 Diabetes: A Randomized Controlled Trial. AJPH, 2011

9/21/12 Heijnsdijk et al. Quality-of-Life Effects of Prostate-Specific Antigen Screening. NEJM, Aug 2012

Schroder et al. Prostate-Cancer Mortality at 11 Years of Follow-up. NEJM, Mar 2012

11/2/12 Rejeski et al. Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes. NEJM, 2012 Schauer et al. Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes. NEJM, April 2012

11/16/12 Sutton et al. Reduced Mortality with Hospital Pay for Performance in England. NEJM, Nov 2012

2/15/13 Sommers et al. Mortality and Access to Care among Adults after State Medicaid Expansions. NEJM, Sept 2011

3/22/13 Dhalla et al. Chlorthalidone Versus Hydrochlorothiazide for the Treatment ofHypertension in Older Adults. Annals of Internal Medicine, 2013

7/22/11 Boceprivir for Untreated Chronic HCV Genotype 1 Infection, Poordad F et al, NEJM, 2011

A New Era of Hepatitis C Therapy Begins, Jensen D, NEJM, 2011

8/26/11 Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women. Park-Wyllie, L et al. JAMA, 2011

9/16/11 Racial and Ethnic Approaches to Community Health (REACH) Detroit Partnership: Improving Diabetes-Related Outcomes Among African American and Latino Adults. Two Feathers J., et al. American Journal of Public Health, 2005

11/18/11 Results of the Medicare Health Support Disease Management Pilot Program, NEJM, Nov 2011

12/16/11 Screening for Prostate Cancer: A Review of the Evidence for the U.S. Preventive Services Task Force, Annals of Internal Medicine, 2011

2/17/12 A Two-Year Randomized Trial of Obesity Treatment in Primary Care Practice, NEJM, Nov 2011

12/29/09 “A Lifeline for Primary Care” by Thomas Bodenheimer, M.D., Kevin Grumbach, MD, New England Journal of Medicine.

12/29/09 “Contribution of Primary Care to Health Systems and Health” by Barbara Starfield, Leiyu Shi, James Macinko. The Milbank Quarterly.

1/29/10 “Screening for Breast Cancer: An Update for the U.S. Preventive Services Task Force” by Heidi D. Nelson et al. Ann Intern Med.

1/29/10 “Effects of Mammography Screening Under Different Screening Schedules: Model Estimates of Potential Benefits and Harms.” Jeanne S. Mandelblatt, et al. Annals of Internal Medicine.

3/10/10 Thinking Outside the Pillbox — Medication Adherence as a Priority for Health Care Reform David M. Cutler, et al. New England Journal of Medicine.

8/11/10 “The Triple Aim: Care, Health, and Cost. The remaining barriers to integrated care are not technical; they are political.” by Donald M. Berwick, Thomas W. Nolan, and John Whittington. Health Affairs.

8/11/10 “The Cost Conundrum.” Gwande, A. The New Yorker, 2009

9/22/10 “The Burden of Blood Pressure-Related Disease A Neglected Priority for Global Health.” Vlado Perkovic, Rachel Huxley, Yangfeng Wu, Dorairaj Prabhakaran, Stephen MacMahon. Hypertension.

12/10/10 “Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study. Vasilios G Athyros, et al. Lancet.

12/28/10 “Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials.” Peter M Rothwell, et al. Lancet.

2/7/11 Genomic Medicine, An Updated Primer. Feero, W. NEJM, 2010, 362:21. Genomics, Type 2 Diabetes, and Obesity. McCarthy, M. NEJM, 2010, 363:24.

3/28/11 Diagnostic Imaging for Low Back Pain: Advice for High Value Health Care from the American College of Physicians. Chou, R. Annals of Internal Medicine, 2011; 154:181-189.

4/22/11 Contextual Errors and Failures in Individualizing Patient Care. Weiner S, et al. Annals of Internal Medicine, 2010;153:69-75