Benjamin Smith, MD, MSc
Location and Contact Information
I am a clinician-scientist and pulmonary physician. I received clinical and research training at McGill and Columbia Universities, and maintain research appointments at both institutions. My research uses translational epidemiology methods to identify, understand, and ultimately target novel COPD endotypes. My research expertise includes thoracic image analysis, respiratory physiology, and epidemiology.
My research focuses on investigating the pathophysiological mechanisms of obstructive lung diseases in order to improve clinically meaningful outcomes. Obstructive lung disease (e.g., chronic obstructive pulmonary disease, asthma) represents a leading cause of morbidity and mortality globally, and in Canada. My research integrates methods of population-based epidemiology, state-of-the-art-imaging, and physiology in order to understand disease pathogenesis and expose targetable mechanisms of functional impairment. My specific areas of interest include airway structure and developmental susceptibility to obstructive lung disease; the personalization of obstructive lung disease prevention and treatment based on airway anatomy; and the cardiotoxic effects of breathing mechanics in obstructive lung disease. My clinical and academic interests include improving the quality of lung cancer diagnosis and staging, and medical education.
Smith BM, Traboulsi H, Austin JHM, Manichaikul A, et al; MESA Lung and SPIROMICS investigators.. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A 2018 Jan 30;115(5):E974-E981.
Kesimer M*, Smith BM*, Ceppe A, Ford AA, et al. Mucin concentration and peripheral airways obstruction in COPD. Am J Resp Crit Care Med 2018 doi: 10.1164/rccm.201806-1016LE.
Abdallah SJ, Wilkinson-Maitland C, Saad N, Li PZ, Smith BM, Bourbeau J, Jensen D. Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomised crossover trial. Eur Respir J 2017 Oct 19;50(4)
Smith BM, Hoffman EA, Rabinowitz D, Bleecker E, et al. Comparison of Spatially Matched Airways Reveals Thinner Airway Walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 2014; 69:987-996.
Smith BM, Austin JH, Newell JD, D’Souza B, et al Pulmonary Emphysema Subtypes on Computed Tomography in Smokers. Am J Med 2014 127(1):e7-e23.
Smith BM, Bluemke DA, Hoffman E, Basner RC, et al. Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study. Circulation 2013; 127:1503-11.
Smith BM, Pinto L, Ezer N, Sverzellati N, et al. Emphysema detected on computed tomography and risk of lung cancer: a systematic review and meta-analysis. Lung Cancer 2012; 77: 58-63.