Benjamin Smith, MD, MS

  • Assistant Professor of Clinical Medicine
Profile Headshot


I am a clinician-scientist and pulmonary physician. I completed clinical and research training at McGill and Columbia Universities and maintain appointments at both institutions. My research expertise includes respiratory medicine, physiology and epidemiology. My research program is focused on understanding what makes certain lungs resilient and others susceptible to lung disease. Specific axes of my research program include i) defining resilient lung structure and function in the 21st century, ii) identifying modifiable etiologic factors in order to promote resilient lung development and maintenance across the lifespan, iii) understanding the mechanisms of increased disease susceptibility and iv) establishing clinical utility of such knowledge.

Academic Appointments

  • Assistant Professor of Clinical Medicine

Credentials & Experience

Education & Training

  • MD, 2005 McGill University
  • MS, 2012 Epidemiology - Emphysema and lung cancer, McGill University
  • Residency: 2008 McGill University
  • Residency: 2010 McGill University
  • Fellowship: 2014 Columbia University Vagelos College of Physicians and Surgeons


Selected Publications

  • Vameghestahbanati M, Sack C, Wysoczanski A, Hoffman EA, et al. Association of dysanapsis with mortality among older adults Eur Resp J 2023 in press (PMID forthcoming)
  • Smith BM, Kirby M, Hoffman EA, et al. Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults. JAMA. 2020;323(22):2268-2280. doi:10.1001/jama.2020.6918
  • Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399(10342):2227-2242. doi:10.1016/S0140-6736(22)00470-6
  • Vameghestahbanati M, Kirby M, Tanabe N, et al. Central Airway Tree Dysanapsis Extends to the Peripheral Airways. Am J Respir Crit Care Med. 2021;203(3):378-381. doi:10.1164/rccm.202007-3025LE
  • Vameghestahbanati M, Kirby M, Maltais F, et al. Dysanapsis and the Spirometric Response to Inhaled Bronchodilators. Am J Respir Crit Care Med. 2021;204(8):997-1001. doi:10.1164/rccm.202107-1574LE
  • Vameghestahbanati M, Hiura GT, Barr RG, Sieren JC, Smith BM, Hoffman EA. CT-Assessed Dysanapsis and Airflow Obstruction in Early and Mid Adulthood. Chest. 2022;161(2):389-391. doi:10.1016/j.chest.2021.08.038
  • Smith BM, Traboulsi H, Austin JHM, et al. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018;115(5):E974-E981. doi:10.1073/pnas.1715564115
  • Smith BM, Hoffman EA, Rabinowitz D, et al. Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014;69(11):987-996. doi:10.1136/thoraxjnl-2014-205160